The cardiovascular benefits of low-dosage acetylsalicylic acid

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Low-dose acetylsalicylic acid for primary prevention of cardiovascular disease: Do not misinterpret the recommendations.

L ow-dose acetylsalicylic acid (ASA) for prevention of cardiovascular disease (CVD), including myocardial infarction (MI) and stroke, is likely something that comes up frequently at family physician appointments. Acetylsalicylic acid has substantial benefits for secondary prevention in most cases. Based on current recommendations, most would also agree that the benefits of ASA (risk reduction o...

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[Health economic evaluation of low-dose acetylsalicylic acid in the primary prevention of cardiovascular disease].

INTRODUCTION AND OBJECTIVES Low-dose aspirin is standard treatment for patients with a history of cardiovascular disease. Its use in primary prevention is more controversial. However, recent studies also support the use of aspirin in high-risk individuals with no history of cardiovascular disease. This study investigated the health economic implications of using low-dose aspirin in the primary ...

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Spectrophotometric and Chromatographic Determination of Acetylsalicylic Acid and Caffeine in Pure and in Tablet Dosage Form

In the present research paper, spectrophotometric and chromatographic assay method has been developed for the simultaneous estimation of acetylsalicylic acid and caffeine in bulk and commercial tablets. Acetylsalicylic acid and caffeine showed absorbance maxima at 228 and 275 nm in 0.1N HCl and at 225 and 272 nm in methanol, respectively. These drugs were estimated in formulations by simultaneo...

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Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid.

A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS). Limited bioequivalence (BE) studies reported in the literature indicate that products that have bee...

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Discontinuation of low-dose acetylsalicylic acid therapy in UK primary care: incidence and predictors in patients with cardiovascular disease

BACKGROUND Discontinuation of low-dose acetylsalicylic acid (ASA) leads to an increased risk of cardiovascular and cerebrovascular events in patients taking low-dose ASA for secondary cardiovascular prevention. However, little is known about the rate of discontinuation in everyday clinical practice. OBJECTIVES To assess the rate of low-dose ASA discontinuation in primary care, and identify fa...

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ژورنال

عنوان ژورنال: Canadian Medical Association Journal

سال: 2019

ISSN: 0820-3946,1488-2329

DOI: 10.1503/cmaj.191037